News
CAP Highlights Molecular Testing to Clarify Difficult-to-Classify Tumors
Authors outline how genomic, transcriptomic, and epigenetic profiling can support pathologists when conventional histology and immunohistochemistry fall short, particularly in cancers of unknown primary and other diagnostically ambiguous tumors.
Study Identifies Reversible Epigenetic Mechanism Behind Prostate Cancer Drug Resistance
Researchers report that treatment resistance in advanced prostate cancer is driven by epigenetic lineage plasticity rather than genetic mutations, raising new possibilities for combination therapies and biomarker development in clinical laboratories.
How tumours trick the brain into shutting down cancer-fighting cells
Lung cancer in mice hijacks neurons to send a signal that subdues the immune system, study finds.
AI Safety in Radiology Partnership Targets Real-World Monitoring and Validation
Radiology Partners and Stanford Radiology’s AI Development and Evaluation Lab have launched a strategic partnership to advance AI safety in radiology through real-world validation and continuous monitoring. The collaboration focuses on how artificial intelligence tools are evaluated once deployed across live clinical environments, where performance, bias, and reliability must be assessed at scale.
New blood test predicts risk of early death more accurately than age
Millions of people worldwide live with high blood sugar, often without realizing it can be life-threatening. Researchers at Hamilton’s Population Health Research Institute (PHRI) have developed a new blood test that uses genetic and biological markers to accurately identify older adults with high blood sugar who are at the highest risk of dying. PHRI is a world-renowned, shared research institute of Hamilton Health Sciences (HHS) and McMaster University.
Detecting concussions with a simple spit test
New technology from Velocity’s HeadFirst can measure concussion biomarkers in saliva and give sports leagues a new way to protect their players
Quantum computers will finally be useful: what’s behind the revolution
Just a few years ago, many researchers in quantum computing thought it would take several decades to develop machines that could solve complex tasks, such as predicting how chemicals react or cracking encrypted text. But now, there is growing hope that such machines could arrive in the next ten years.
Molecular signature of sleeping nociceptors offers new pain targets
Researchers from the Centre for Addiction and Mental Health (CAMH) and the Institute of Neurophysiology at Uniklinik RWTH Aachen in Germany have deciphered the molecular signature of so-called sleeping nociceptors-a type of pain-sensing nerve cell that normally remains quiet and does not respond to touch or pressure, but can become overactive and drive chronic pain.
ADLM Guidance Urges Labs to Rethink Emergency Department Drug Testing
New recommendations highlight the limited impact of routine urine drug testing in the ED while calling on laboratories to refine test menus, expand fentanyl screening, and improve clinician education to better support trauma care, behavioral health referrals, and evolving regulatory demands.
Low-intensity pulsed ultrasound shows promise for ovarian function restoration
Conventional hormone replacement therapy (HRT) alleviates menopausal symptoms but carries potential risks, such as breast malignancies, and does not restore ovarian endocrine function. As a noninvasive physical therapy, low-intensity pulsed ultrasound (LIPUS) regulates cell proliferation, apoptosis, inflammation, and angiogenesis through mechanical stress, cavitation effects, and microstreaming, thus providing a novel therapeutic avenue for premature ovarian insufficiency.
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