Introduction
We appreciate you taking the time to read LabBuzz. This is a CSMLS venture to provide relevant medical laboratory news and research to members. The articles have been condensed to provide an introduction on the topics. Please refer to the original article for the complete text.
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News
Blood-Based Biomarkers Help Predict Outcomes after Traumatic Brain Injury
A study funded by the National Institutes of Health found that biomarkers present in the blood on the day of a traumatic brain injury (TBI) can accurately predict a patient’s risk of death or severe disability six months later.
Medical Laboratories Respond to Monkeypox Outbreak Using CDC-Developed Diagnostic Test
Medical laboratories in the US are ramping up their efforts to respond to an outbreak of monkeypox that has been spreading around the globe. Microbiologists and clinical laboratory scientists will be interested to learn that this infectious agent—which is new to the US—may be establishing itself in the wild rodent population in this country.
Nanoparticle-based lateral flow immunoassay for the detection of anti-SARS-CoV-2 neutralizing antibodies
Although organic luminogens with aggregation-induced emission (AIEgens) exhibits bright fluorescence at high concentration, their nanocrystal form cannot conjugate with antibodies and cannot be released from the pad. Hence, their utilization in ultrabright AIEgen nanocrystals in lateral flow immunoassays (LIFA) is restricted. A proper format for introducing ultrabright AIEgens into LIFA is required to overcome this restriction.
Treating Disease with E. coli Engineered from Stool Samples
Scientists have long tried to introduce genetically engineered bacteria into the gut to treat diseases. In the past, these attempts have focused on engineering common lab strains of E. coli, which cannot compete with the native gut bacteria that are well adapted to their host. Now, a group of researchers from the University of California, San Diego, successfully engineered E. coli collected from both human and mice gut microbiomes and showed that they have the potential to treat diseases such as diabetes.
International Team of Scientists Use Genetic Testing to Solve Centuries-Old Mystery of Black Death’s Origin
Microbiologists and clinical laboratory scientists will likely find it fascinating that an international team of scientists may have solved one of history’s greatest mysteries—the origin of the bubonic plague that ravaged Afro-Eurasia in the mid fourteenth century. Also known as the Black Death, the plague killed 60% of the population of Europe, Asia, and North Africa between 1346-1353 and, until now, the original source of this disease has largely gone unsolved.
Study finds climate hazards can aggravate over half of known human infectious diseases
Although it is well-established that climate change influences pathogenic illnesses, the degree of human susceptibility to the pathogenic diseases impacted by climatic alteration is unknown and is the focus of this study.
Children with Genetic Disorders More Likely to Also Have Mental Health Problems
A major study of children with intellectual disabilities has highlighted the additional challenges that they often face, including a much-increased likelihood of being diagnosed as autistic, as well as Attention Deficit Hyperactivity Disorder (ADHD) and other mental health difficulties.
Study defines how the circadian clock influences cell growth, metabolism and tumor progression
In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC).
A Chance to Reduce Unneeded Blood Tests
Alert in doctors’ ordering system about scarce supplies leads to 29 percent drop in blood clotting tests.
Novel Molecular Biomarkers in Cells That Spread a Deadly Form of Breast Cancer
Studying a deadly type of breast cancer called triple negative, Johns Hopkins Medicine scientists say they have identified key molecular differences between cancer cells that cling to an initial tumor and those that venture off to form distant tumors.
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